Is there a gap between how you'd like things to be and how they are?
It may be a small gap or a freaking enormous ravine, but that gap is, in fact, probably the primary cause of pain and unhappiness for most people. What if you said 'F**k It' to the idea of how your life should be and found peace with your life just as it is? That's going to shake things up and take the edge o your pain and discomfort way more than any pill could.
John C. Parkin, the maestro of saying 'F**k It', realized as he worked with people on his retreats that we can close that gap not by striving to be dfferent, changing the world or even learning how to peaceful - but by saying 'F**k It' and making our peace with life, just as it is. Being at peace with life doesn't necessarily mean being peaceful, and it certainly isn't being passive; it means embracing life in all its colours.
This is a radical message that can create radical shifts in your perception of life, just as it is.